No, it doesn't work. If the assassin was ruthless, why is she still alive?
How about a neophyte assassin who this is his first assignment?
And what if he falls in love with her? And what if he knows why her memories where taken from her; and know if she ever regains her memories, she would totally hate him? And no, he is not thinking about sex, but marriage. Yeah, somehow he's committed. (It happens.) (Of course, the story is no longer about her, but him. At this point, the emotional conflict is about what he experiences; and you end up writing a story you never envisioned from the start.
No, I don't find specific goals worth while. That's not to say that a distance target may be worth pursuing. But with a collaborative story, you have to be flexible.
And may I point out that not all stories are about a clash between the protagonist and the antagonist. Marion Zimmer Bradley's The Mist of Avalon is more about biological work than a story; there is no clear antagonist in it.






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