Somewhat tangential to your question....
In one of the Granddaddies of Sci-Fi, The Foundation series by Isaac Asimov, Dr. Asimov writes
No, Riders of the Purple Sage (Wage?) wasn't in it. But considering he wrote well over 100 short stories it would be hard to all of his best in 1 book.
Laer -- We all love ya', but this was too tasty to pass up. Cheer up, we all do it. -- WB
Are you going to have people in zero gravity or not?
I don't know if there are any descriptions by astronauts of their personal experiences
I would think the first thing necessary is to lock down your reader market, and my own opinion on the matter is that you don't try and cross markets because